Nociceptor α7nAChR activation blunts neuronal HMGB1 release and attenuates inflammation and nociceptive behavior
This study reveals a novel α7nAChR-dependent cholinergic mechanism that reduces nociceptive behavior and inflammation by retaining nuclear HMGB1 in nociceptors. Cholinergic agonists may serve as promising therapeutic agents to mitigate nociceptive behavior and inflammation by targeting α7nAChR in sensory neurons.
Authors
- Tyler D. Hepler
- Timothy W. Morgan
- Michael Brines (ORCID: https://orcid.org/0000-0003-4151-4449)
- Kevin J. Tracey (ORCID: https://orcid.org/0000-0003-1884-6314)
- Aisling Tynan (ORCID: https://orcid.org/0000-0002-6856-2259)
- Okito Hashimoto (ORCID: https://orcid.org/0000-0002-6183-6085)
- Saher Chaudhry
- Jan Andersson (ORCID: https://orcid.org/0000-0003-0316-3860)
- Sangeeta S. Chavan (ORCID: https://orcid.org/0000-0002-4822-3356)
- Huan Yang (ORCID: https://orcid.org/0000-0002-3106-490X)
- Serena Petruzzelli
Institutions
- Feinstein Institute for Medical Research (US)
- Karolinska University Hospital (SE)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s10020-025-01387-z
- Citations
- 1
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- National Institutes of Health
- National Institute of General Medical Sciences