Dynamic evolution of NK cells and immune remodeling mediated by CRS + HIPEC: prognostic mechanisms and therapeutic implications for malignant peritoneal mesothelioma
Preoperative NK depletion correlated with thrombosis and surgical risks, while postoperative NK recovery was influenced by KPS, specific cytokines (IL-4/5/6/8), and was significantly enhanced after CRS + HIPEC.
Authors
- Yu‐Bin Fu
- Yan‐Dong Su
- Ru Ma (ORCID: https://orcid.org/0000-0002-6843-5129)
- Yong Cui (ORCID: https://orcid.org/0000-0002-3658-1770)
- Tian Wei (ORCID: https://orcid.org/0000-0002-0612-0076)
- Xin‐Li Liang (ORCID: https://orcid.org/0000-0001-8644-2886)
- He‐Liang Wu (ORCID: https://orcid.org/0009-0008-8842-0347)
- Rui Yang (ORCID: https://orcid.org/0000-0003-2291-4914)
- Yan Li (ORCID: https://orcid.org/0000-0001-6018-6538)
- Bing Li (ORCID: https://orcid.org/0000-0002-6575-4423)
- Yitong Liu (ORCID: https://orcid.org/0000-0003-0728-3018)
- Yang Yu (ORCID: https://orcid.org/0000-0002-8482-4626)
- Qidi Zhao
Institutions
- Capital Medical University (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s12957-025-04019-2
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Municipal Administration of Hospitals