Progressive increases in adiposity and ectopic fat surrogates across glycaemic states highlight weight reduction as a key target for type 2 diabetes prevention, especially in younger people

Deteriorating glycaemic status was marked by progressively higher levels of adiposity and circulating and hepatic ectopic fat markers. Findings were more pronounced in younger individuals, suggesting a greater role for ectopic fat in their diabetes and reinforcing the importance of weight intervention for preventing the progression from normoglycaemia to prediabetes to frank diabetes.