Abstract 4360094: Trends in Hypertension-Related Heart Failure Mortality in the United States (1999–2020): A Population-Based Study

Background: Hypertension is increased blood pressure above 140/90mmHg. Novel therapeutics toward Hypertension have shown improvement in cardiovascular activity. However, patients with hypertension have shown an increased risk of heart failure (HF). We aim to analyze the trends of mortality in people with HF and Hypertension in the adult US population. Objectives: The purpose of this study was to assess the trends and regional differences in Hypertension and HF related mortality among older adults (≥65) in the United States. Methods: CDC WONDER(Center for disease control and prevention Wide-Ranging Online Database for Epidemiologic Research) database was examined from 1999 to 2020. The study population included U.S. adults aged 65+ years, with hypertension-related heart failure. ICD-10 codes were used, I10–I50 as underlying causes and I50 as a multiple cause of death. Age-adjusted mortality rates (AAMR) were calculated per 100,000. Annual percent change (APC) was estimated to assess mortality trends over time. Analyses were stratified by sex, race, state, place of death, and U.S. census region. The Midwest region and American Indian/Alaska Native population were excluded. Analysis was done through joinpoint. Results: Between 1999 and 2020, 259,079 deaths occurred from hypertension related HF. The AAMR rose from 11.27 in 1999 to 21.723 in 2000, and the highest AAMR reported was 41.05 in 2020. Females showed higher AAMR (women = 41.09 vs men = 40.18). Nursing home/Long term care facilities accounted for 36.06% of all places of death followed by Descendants Home with 30.05%. Racial groups showed highest mortality in Blacks/African Americans (53.59) followed by White (40.58), lower AAMR in Hispanic/Latino (31.92) and Asian/Pacific Islanders (24.21). The Western Region reported the highest AAMR (49.87). Conclusion: Hypertension-related heart failure mortality among U.S. adults aged 65+ increased from 1999 to 2020, with higher rates in females, Black individuals, and the Western region. Disparities by race, sex, and place of death highlight the need for targeted public health efforts and improved care in long-term settings.