CLIP2: a novel functional player in AQP5 trafficking dynamics and implications for Sjögren’s disease
Our study identifies CLIP2 as a novel player in the AQP5 interactome and sheds light on its crucial role in AQP5 trafficking. In SjD, the alterations in AQP5-CLIP2 interactions and the presence of autoantibodies against both proteins highlighted their potential as targets for future therapeutic interventions in SjD.
Authors
- Stefania Moscato (ORCID: https://orcid.org/0000-0001-9283-6902)
- Dorian Parisis (ORCID: https://orcid.org/0000-0001-7033-2084)
- Natalija Filipović (ORCID: https://orcid.org/0000-0002-8943-4109)
- Thomas E. Dorner (ORCID: https://orcid.org/0000-0002-5218-1160)
- Fiona Engelke (ORCID: https://orcid.org/0000-0002-5673-1705)
- Carl Johan Hagströmer (ORCID: https://orcid.org/0000-0002-2088-7281)
- Azine Datlibagi (ORCID: https://orcid.org/0000-0003-0049-9983)
- Françoise Grégoire (ORCID: https://orcid.org/0000-0003-0452-8868)
- Jason Perret (ORCID: https://orcid.org/0000-0001-7161-7604)
- Nargis Bolaky
- Letizia Mattii (ORCID: https://orcid.org/0000-0001-6835-7987)
- Torsten Witte (ORCID: https://orcid.org/0000-0003-4531-0267)
- Kevin L. Schey (ORCID: https://orcid.org/0000-0002-3959-1712)
- Helin Strandberg (ORCID: https://orcid.org/0009-0005-5592-4926)
- Maxime Tarabichi (ORCID: https://orcid.org/0000-0002-1635-2348)
- Susanna Törnroth‐Horsefield (ORCID: https://orcid.org/0000-0002-9435-8243)
- Muhammad Shahnawaz Soyfoo (ORCID: https://orcid.org/0000-0002-9051-1810)
- Christine Delporte (ORCID: https://orcid.org/0000-0003-0385-5824)
- Egor Zindy (ORCID: https://orcid.org/0000-0003-0033-0002)
- Louise Conrard (ORCID: https://orcid.org/0009-0007-3177-5158)
- Zhen Wang (ORCID: https://orcid.org/0000-0003-3173-6961)
- Claudia D’Agostino (ORCID: https://orcid.org/0000-0003-3537-2181)
- A G Nash
Institutions
- University of Pisa (IT)
- Université Libre de Bruxelles (BE)
- Lund University (SE)
- Vanderbilt University (US)
- Medizinische Hochschule Hannover (DE)
- German Rheumatism Research Centre (DE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s12964-025-02476-6
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Tokushima
- Università degli Studi di Udine
- Division of Civil, Mechanical and Manufacturing Innovation