Cell-type-specific dysregulation of mitochondrial calcium signaling in Alzheimer’s disease
This study reveals cell-type-specific differences in <sub>m</sub>Ca<sup>2+</sup> signaling and mitochondrial function in AD, uncovering unique vulnerabilities in neuroblastoma-derived and glial-like cells. These findings highlight the need for cell-targeted strategies to restore <sub>m</sub>Ca<sup>2+</sup> homeostasis and mitochondrial function in AD.
Authors
- Dhanendra Tomar (ORCID: https://orcid.org/0000-0002-3144-7257)
- Kasturi Samantaray
- Shanikumar Goyani
- Shatakshi Shukla
- Natasha Jaiswal (ORCID: https://orcid.org/0000-0003-4666-5430)
- Ashlesha Kadam (ORCID: https://orcid.org/0000-0003-4787-2597)
- Pooja Jadiya (ORCID: https://orcid.org/0000-0003-4807-9304)
- Shiridhar Kashyap (ORCID: https://orcid.org/0000-0002-1695-7566)
Institutions
- Wake Forest University (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s12964-025-02460-0
- Citations
- 2
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Alzheimer's Association
- American Heart Association
- National Institutes of Health