Excellence in oncology care (EIOC) consensus guidelines on the use of liquid biopsy and targeted therapy in early-stage and locally advanced non-small cell lung cancer (NSCLC) for the Middle East and Indian subcontinent

ABSTRACT The Excellence in Oncology Care (EIOC) 2023 Congress, held in Dubai as a hybrid event, brought together oncologists from the Middle East and the Indian subcontinent. Two panels, comprising 33 experts, developed the first region-specific consensus guidelines to address critical issues in non-small cell lung cancer (NSCLC), particularly focusing on the roles of liquid biopsy and targeted therapies in early-stage cancer. These guidelines, created through surveys and preparatory meetings, were presented and discussed at the congress, both in person and online. While tissue biopsies remain the gold standard, liquid biopsies are emerging as a promising, minimally invasive alternative, though they are hampered by a lack of standardization and logistical challenges in the region. Liquid biopsy supports follow-up by accessing circulating tumor DNA, though its utilization is limited by infrastructure and costs. In the Middle East and the Indian subcontinent, the adoption of liquid biopsy is constrained by logistical hurdles, financial limitations, and inadequate infrastructure. The EIOC panels provided consensus statements on employing liquid biopsy and integrating targeted therapy in early-stage and locally advanced NSCLC for this region. The consensus highlighted the importance of combining liquid and tissue biopsies, especially for detecting resistance mutations and driver alterations, such as EGFR and ALK, with recommendations for incorporating targeted therapy and chemotherapy. This consensus aims to assist regional clinicians in navigating the evolving landscape of NSCLC management.

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Publication Details

Journal
Cancer Research Statistics and Treatment
Published
2025-10-01
DOI
https://doi.org/10.4103/crst.crst_14_25
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
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article

Excellence in oncology care (EIOC) consensus guidelines on the use of liquid biopsy and targeted therapy in early-stage and locally advanced non-small cell lung cancer (NSCLC) for the Middle East and Indian subcontinent

Navneet Singh, Apar Kishor Ganti, Shamshad Akram, Arun Karanwal et al.
Cancer Research Statistics and Treatment
Lung Cancer Treatments and Mutations
article

Excellence in oncology care (EIOC) consensus guidelines on the use of liquid biopsy and targeted therapy in early-stage and locally advanced non-small cell lung cancer (NSCLC) for the Middle East and Indian subcontinent

Navneet Singh, Apar Kishor Ganti, Shamshad Akram, Arun Karanwal, Maroun Khoury, Sushama Shelke, Vijay Patil, Akhil Kapoor, Omshree Shetty, Nivedita Chakrabarty, Bijesh Yadav, Yasmin Abdul Rashid, Alfredo Addeo, Vidya Veldore, Madala Ravikrishna, Christine M. Lovly, Diaeddine Trad, Amit Dutt, Shaheenah Dawood, Venkatesh Kapu, Nouri Bennini, Ajay Singh, Rajiv Kumar, Mostafa Aziz, Sajan Thapa, Minit Shah, Gowhar Shafi, Prashant Kumar, Chirantan Bose, Vanita Noronha, Anu Iris
article en

Abstract

ABSTRACT The Excellence in Oncology Care (EIOC) 2023 Congress, held in Dubai as a hybrid event, brought together oncologists from the Middle East and the Indian subcontinent. Two panels, comprising 33 experts, developed the first region-specific consensus guidelines to address critical issues in non-small cell lung cancer (NSCLC), particularly focusing on the roles of liquid biopsy and targeted therapies in early-stage cancer. These guidelines, created through surveys and preparatory meetings, were presented and discussed at the congress, both in person and online. While tissue biopsies remain the gold standard, liquid biopsies are emerging as a promising, minimally invasive alternative, though they are hampered by a lack of standardization and logistical challenges in the region. Liquid biopsy supports follow-up by accessing circulating tumor DNA, though its utilization is limited by infrastructure and costs. In the Middle East and the Indian subcontinent, the adoption of liquid biopsy is constrained by logistical hurdles, financial limitations, and inadequate infrastructure. The EIOC panels provided consensus statements on employing liquid biopsy and integrating targeted therapy in early-stage and locally advanced NSCLC for this region. The consensus highlighted the importance of combining liquid and tissue biopsies, especially for detecting resistance mutations and driver alterations, such as EGFR and ALK, with recommendations for incorporating targeted therapy and chemotherapy. This consensus aims to assist regional clinicians in navigating the evolving landscape of NSCLC management.

Cancer Research Statistics and TreatmentVol. 8(4)
Purbanchal University (NP), University of Delhi (IN), Aga Khan University (PK), Homi Bhabha National Institute (IN), Tata Memorial Hospital (IN), P. D. Hinduja Hospital and Medical Research Centre (IN), Cancer Institute (WIA) (IN), Dubai Hospital (AE), Tawam Hospital (AE), Biotech Park (IN), B.P. Koirala Memorial Cancer Hospital (NP), University Hospital of Geneva (CH), Dhaka Community Hospital Trust (BD), MemorialCare Health System (US), Mediclinic City Hospital (AE), Datar Cancer Genetics (India) (IN), Square Hospitals (BD), Dubai Medical College (AE), VA Nebraska Western Iowa Health Care System (US), Themis (India) (IN), Post Graduate Institute of Medical Education and Research (IN), Vanderbilt University Medical Center (US)
Openalex Percentile: Top 54%
Lung Cancer Treatments and Mutations
DOIOpen Access PDFOpenAlex
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