Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients With Chronic Kidney Disease
Collectively, our human subject and mouse studies show that circulating CKD-EVs, carrying distinct renal-derived miRNAs, mediate the molecular crosstalk that contributes to the pathogenesis of heart failure in CKD. Consequently, CKD-EVs hold promise as diagnostic and prognostic biomarkers for early disease detection and as targets for novel therapeutic interventions in chronic reno-cardiac disease.
Authors
- Carlos G. Santos‐Gallego (ORCID: https://orcid.org/0000-0003-1408-8958)
- Carol J. Levy (ORCID: https://orcid.org/0000-0002-3492-2578)
- Seonghun Yoon (ORCID: https://orcid.org/0009-0009-5498-4053)
- Uta Erdbrügger
- Susmita Sahoo (ORCID: https://orcid.org/0000-0002-7279-1564)
- Xisheng Li (ORCID: https://orcid.org/0000-0001-8172-5342)
- Hayrettin Yavuz (ORCID: https://orcid.org/0000-0001-5190-7022)
- David Sachs (ORCID: https://orcid.org/0000-0002-4445-2055)
- Rupangi C. Vasavada (ORCID: https://orcid.org/0000-0003-3228-9235)
- Sabrina La Salvia (ORCID: https://orcid.org/0000-0002-2988-137X)
- Michael A. Harding (ORCID: https://orcid.org/0000-0001-8636-067X)
- Navneet Dogra (ORCID: https://orcid.org/0000-0002-4602-3991)
- Nicole Dubois (ORCID: https://orcid.org/0000-0002-8467-3004)
- Alex Gallinat (ORCID: https://orcid.org/0000-0002-1521-2175)
- Nikhil Raisinghani
- Shihong Zhang (ORCID: https://orcid.org/0000-0002-9661-1089)
- Anita Phan (ORCID: https://orcid.org/0000-0002-3288-6091)
- Alan Shao
Institutions
- City of Hope (US)
- Child Health and Development Institute (US)
- University of Virginia (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1161/circulationaha.125.075579
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00