Dimethyl fumarate alleviates inflammation during high altitude hypoxia induced acute lung injury by upregulating Nrf2/SLC7A11 pathway in ferroptosis
This study revealed that a reciprocal regulatory relationship between ferroptosis of lung epithelial cells and macrophage-mediated inflammation was one of the critical mechanisms contributing to HA exposure triggered ALI. Furthermore, DMF could alleviates hypoxia induced ALI by upregulating Nrf2/SLC7A11 pathway, making it a potential protective agent against HA hypoxia induced ALI.
Authors
- Jie Huang (ORCID: https://orcid.org/0000-0001-7951-2217)
- Yujie Wei (ORCID: https://orcid.org/0000-0002-3213-7891)
- Chi Chiu Wang (ORCID: https://orcid.org/0000-0002-3928-7278)
- Qi Wang (ORCID: https://orcid.org/0000-0002-5287-6050)
- Ting Liu (ORCID: https://orcid.org/0000-0003-1816-5551)
- Chengbin Wang (ORCID: https://orcid.org/0000-0002-6535-5967)
- Liye Wang
- Haoran Guo (ORCID: https://orcid.org/0000-0001-8244-5545)
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Clinical Proteomics
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s12014-025-09566-0
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52