Abstract 4371983: Gonococcal Endocarditis of the Native Aortic Valve: A Rare but Aggressive Cause of Valvular Destruction

Introduction: Gonococcal infective endocarditis (IE) is a rare but aggressive complication of disseminated gonococcal infection (DGI), occurring in only 1–2% of DGI cases. While DGI typically presents as a triad of arthralgia, tenosynovitis, and skin lesions, cardiac involvement is very uncommon and often easily missed. We report a unique case of gonococcal IE in a healthy young male without any genitourinary symptoms. Case Presentation: A 24-year-old male with no past medical history presented to the ED with dull, non-radiating substernal chest pain, worsened by rest and relieved by leaning forward. Vital signs revealed a temperature of 100.3°F and a heart rate of 120 bpm. Physical examination noted a grade 3/6 diastolic murmur, loudest at the left upper sternal border. He denied IV drug use but reported remote oral and vaginal sexual encounters. Transthoracic echocardiography (TTE) showed an ejection fraction of 58% with a mobile echodensity on the aortic valve, severe aortic regurgitation, and holo-diastolic flow reversal in the descending aorta. Transesophageal echocardiography (TEE) confirmed a 1.4 × 0.8 cm mobile echogenic mass consistent with vegetation, and an abscess in the right coronary part of the aortic annulus. The patient was started on broad-spectrum antibiotics, including vancomycin and ampicillin-sulbactam. Intraoperatively, vegetations were observed on the left and right coronary leaflets, with a small perivalvular abscess at the left-right coronary commissure. The aortic valve was reconstructed with a mechanical valve. Blood cultures and throat swabs were positive for Neisseria gonorrhoeae. Surgical pathology revealed moderate to severe acute and chronic inflammation, consistent with acute/subacute infective endocarditis, although tissue Gram stain was negative for definitive bacteria. Conclusion: Gonococcal IE is an exceedingly rare yet life-threatening entity, with reported mortality rates of 19–20%, likely due to rapid valvular destruction and large vegetations. Interestingly, valve cultures are often sterile, so diagnosis typically relies on blood or mucosal cultures. Given the potentially devastating consequences of delayed recognition, this case emphasizes the importance of considering gonococcal etiology in endocarditis, particularly in young, sexually active individuals without classic symptoms. Reporting such cases helps towards forming evidence-based treatment guidelines and strengthening awareness of this rare presentation.