Vaccine effectiveness against influenza A in older adults and the effect of chronic conditions: results from the I-MOVE and VEBIS multicentre European hospital case–control studies, 2015/16–2023/24
Pooled-season results suggest low-moderate VE against influenza A subtypes among older SARI patients; higher against A(H1N1)pdm09 than A(H3N2), with little evidence of chronic condition modifying effect, apart from kidney disease and immunosuppression. We stress the importance of developing improved influenza vaccines for specific populations, and encourage further research into the effect of chronic conditions on IVE in older adults.
Authors
- Silvia Bino (ORCID: https://orcid.org/0000-0003-0565-863X)
- Ivan Mlinarić (ORCID: https://orcid.org/0009-0008-8546-6331)
- Marcos Iglesias (ORCID: https://orcid.org/0000-0002-7523-5950)
- Rianne van Gageldonk-Lafeber (ORCID: https://orcid.org/0000-0002-0342-2087)
- Silke Buda (ORCID: https://orcid.org/0000-0003-3448-3357)
- Kristin Tolksdorf (ORCID: https://orcid.org/0000-0002-8712-6399)
- Mihaela Lazăr (ORCID: https://orcid.org/0000-0002-8226-6026)
- Lisa Domegan (ORCID: https://orcid.org/0000-0002-7483-6703)
- Ana Miqueleiz
- Isabela Ioana Loghin (ORCID: https://orcid.org/0000-0002-1327-6511)
- Ana Navascués (ORCID: https://orcid.org/0000-0002-1372-9680)
- Roberta Vaikutytė (ORCID: https://orcid.org/0000-0002-5992-7746)
- Alina Elena Ivanciuc (ORCID: https://orcid.org/0000-0002-2947-3800)
- Petr Husa (ORCID: https://orcid.org/0000-0002-9190-2610)
- Verónica Gomez (ORCID: https://orcid.org/0000-0003-0485-0005)
- Liliana Dias
- Barbara Biere (ORCID: https://orcid.org/0000-0001-6988-3735)
- Nuno Verdasca (ORCID: https://orcid.org/0000-0002-4673-5411)
- Guillermo Ezpeleta (ORCID: https://orcid.org/0000-0003-0970-6352)
- Zvjezdana Lovrić Makarić (ORCID: https://orcid.org/0000-0003-4285-2116)
- Terra Fatukasi (ORCID: https://orcid.org/0000-0003-3287-1831)
- Gergő Túri (ORCID: https://orcid.org/0000-0003-3465-8321)
- Goranka Petrović (ORCID: https://orcid.org/0000-0001-8304-5519)
- Cristina Burgui (ORCID: https://orcid.org/0000-0002-9099-6117)
- Flavia Riccardo (ORCID: https://orcid.org/0000-0002-1582-6329)
- Marianne Wedde
- Manuel Garcìa Cenoz (ORCID: https://orcid.org/0000-0001-7316-9104)
- Francisco del Pozo (ORCID: https://orcid.org/0000-0001-9919-9125)
- Carmen Ezpeleta
- Esther Kissling (ORCID: https://orcid.org/0000-0001-7188-8404)
- André Almeida (ORCID: https://orcid.org/0000-0002-8192-6424)
- Miguel Fernández-Huerta (ORCID: https://orcid.org/0000-0002-1733-0925)
- Miriam Latorre-Millán (ORCID: https://orcid.org/0000-0001-9932-0124)
- Adela Vasili
- Gloria Pérez‐Gimeno (ORCID: https://orcid.org/0000-0003-3435-4854)
- Paula Pinto (ORCID: https://orcid.org/0000-0003-2301-2752)
- Birutė Zablockienė (ORCID: https://orcid.org/0000-0001-8519-6265)
- Paula Lopes (ORCID: https://orcid.org/0000-0002-2150-051X)
- Martina Zajec
- Gerd Xuereb (ORCID: https://orcid.org/0000-0001-8037-4982)
- Nerea Egüés
- Iwona Paradowska‐Stankiewicz (ORCID: https://orcid.org/0000-0001-7222-1337)
- Corneliu Petru Popescu (ORCID: https://orcid.org/0000-0001-6316-0333)
- Irena Tabain (ORCID: https://orcid.org/0000-0002-2518-522X)
- Iva Pem Novosel
- Francesco Genderini
- Sigi Van den Wijngaert (ORCID: https://orcid.org/0000-0002-8623-2165)
- Annamária Ferenczi (ORCID: https://orcid.org/0000-0002-2597-3867)
- Lenka Součková (ORCID: https://orcid.org/0000-0003-0028-4464)
- Antonino Bella (ORCID: https://orcid.org/0000-0002-6615-4227)
- Sanja Filipović (ORCID: https://orcid.org/0000-0001-8166-8042)
- Beatrix Oroszi (ORCID: https://orcid.org/0000-0001-8915-0336)
- Itziar Casado (ORCID: https://orcid.org/0000-0001-6879-4984)
- Bánk G. Fenyves (ORCID: https://orcid.org/0000-0003-2374-7513)
- Laurane De Mot
- Bernadett Burkali
- Ralf Dürrwald (ORCID: https://orcid.org/0000-0002-3432-0438)
- Petra Smoljo
- J Horváth (ORCID: https://orcid.org/0009-0001-7402-3227)
- Alberto Mateo‐Urdiales (ORCID: https://orcid.org/0000-0002-0480-8723)
- Monika Kuliešė (ORCID: https://orcid.org/0000-0002-4601-4585)
- Odette Popovici (ORCID: https://orcid.org/0000-0003-4157-2622)
- Sierk Marbus (ORCID: https://orcid.org/0000-0002-7457-6964)
- Sabrina Bacci (ORCID: https://orcid.org/0000-0002-6575-3439)
- Charlene Bennett
- José Poças
- Nicolás Dauby (ORCID: https://orcid.org/0000-0002-7697-6849)
- Nathalie Nicolay (ORCID: https://orcid.org/0000-0002-5916-7855)
- Odile Launay (ORCID: https://orcid.org/0000-0003-3242-7247)
- Jennifer Howard (ORCID: https://orcid.org/0009-0008-1930-8693)
- Angela MC Rose (ORCID: https://orcid.org/0000-0002-2493-8082)
- Rita Côrte‐Real
- Carolin Hackmann (ORCID: https://orcid.org/0000-0001-8788-3632)
- Vesna Višekruna Vučina (ORCID: https://orcid.org/0009-0009-8954-6846)
- Kevin Marsh (ORCID: https://orcid.org/0000-0001-8377-5466)
- Auksė Mickienė (ORCID: https://orcid.org/0000-0002-4998-1319)
- Márta Knausz (ORCID: https://orcid.org/0000-0002-8167-9822)
- Ana Milagro (ORCID: https://orcid.org/0000-0002-3888-8952)
- Ligita Jančorienė (ORCID: https://orcid.org/0000-0001-6488-6312)
- Camino Trobajo‐Sanmartín (ORCID: https://orcid.org/0000-0001-5105-252X)
- Ute Preuß
- Cristina Bárbara (ORCID: https://orcid.org/0000-0003-0915-4105)
- Giedrė Gefenaitė (ORCID: https://orcid.org/0000-0001-9952-9446)
- Bernard Kaić (ORCID: https://orcid.org/0009-0008-9377-1395)
- Clara Mazagatos (ORCID: https://orcid.org/0000-0002-6909-6923)
- Joan O’Donnell (ORCID: https://orcid.org/0000-0002-2662-6306)
- Janine Reiche (ORCID: https://orcid.org/0000-0003-2541-1095)
- Victor Gomes
- Margaret G. Fitzgerald (ORCID: https://orcid.org/0000-0002-4535-0966)
- António Pais de Lacerda (ORCID: https://orcid.org/0000-0002-3001-8848)
- Iván Martínez‐Baz (ORCID: https://orcid.org/0000-0002-3405-2277)
- Csaba Varga (ORCID: https://orcid.org/0009-0005-2045-8451)
- Débora Lima Pereira (ORCID: https://orcid.org/0000-0003-4875-746X)
- Daniela Dias (ORCID: https://orcid.org/0009-0006-6744-0571)
- Jim McMenamin (ORCID: https://orcid.org/0000-0002-5697-0335)
- Maja Ilić (ORCID: https://orcid.org/0000-0001-7709-1797)
- Margarida Tavares (ORCID: https://orcid.org/0000-0002-9544-0484)
- Ana Paula Rodrigues
- Ausenda Machado
- Joanna Bogusz
- Krisztina Mucsányiné Juhász
- Licínia Gomes (ORCID: https://orcid.org/0009-0009-0214-9646)
- Jesús Castilla
- Maria João Peres
- Stephen Abela
- Raquel Guiomar
- Róisín Duffy (ORCID: https://orcid.org/0009-0001-7169-9109)
- Aitziber Echeverría (ORCID: https://orcid.org/0009-0002-2822-819X)
- Heidi Gruner
- Liem Binh Luong Nguyen
- António Panarra
- J. E. A. O'Connell
- Annika Erdwiens
- Viktória Velkey
- Koloman Krištof (ORCID: https://orcid.org/0000-0003-1573-4667)
- Gabriella Kollár
Institutions
- Semmelweis University (HU)
- University of Medicine Tirana (AL)
- Lithuanian University of Health Sciences (LT)
- Université Libre de Bruxelles (BE)
- Inserm (FR)
- Vilnius University (LT)
- Université Paris Cité (FR)
- Masaryk University (CZ)
- Robert Koch Institute (DE)
- Istituto Superiore di Sanità (IT)
- Mater Dei Hospital (MT)
- Instituto de Salud Carlos III (ES)
- Health Service Executive (IE)
- Instituto de Salud Pública de Navarra (ES)
- Institute of Public Health (AL)
- Hôpital Cochin (FR)
- Hrvatski zavod za javno zdravstvo (HR)
- Narodowy Instytut Zdrowia Publicznego PZH – Państwowy Instytut Badawczy (PL)
- University Hospital Brno (CZ)
- National Institute for Public Health and the Environment (NL)
- Institutul Cantacuzino (RO)
- Hospital Universitario Miguel Servet (ES)
- Public Health Scotland (GB)
- Health Protection Surveillance Centre (IE)
- National Institute of Health Dr. Ricardo Jorge (PT)
- Sciensano (Belgium) (BE)
- Centre Hospitalier Universitaire de Saint-Pierre (BE)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Vesticon (United States) (US)
- European Centre for Disease Prevention and Control (SE)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s12916-025-04426-y
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- National Research, Development and Innovation Office