Occurrence and predictors of patient reported fertility discussions in non-Hodgkin lymphoma patients: utilizing the lymphoma epidemiology of outcomes (LEO) cohort study
Patients with non-Hodgkin lymphoma (NHL), especially younger individuals, can face fertility risks from treatment. We assessed rates and predictors of fertility counseling and preservation in this population. The LEO cohort prospectively enrolled newly diagnosed NHL patients (2015-2020) at eight U.S. academic centers. We assessed responses to a 3-year survivorship questionnaire in those aged 18-50 at diagnosis; logistic regression evaluated predictors of fertility counseling. Of 77 respondents included (46% female, median age 40), 72.2% of females and 58.5% of males recalled having a fertility discussion at diagnosis. Fertility counseling was more likely to occur in those aged 18-39 versus 40-50 (OR 10.2, 95% CI 3.3-39.2) and in those receiving alkylating therapy (OR 9.0, 95% CI 2.3-45.5). Interventions are still needed to ensure adequate survivorship care.
Authors
- Jonathon Brett Cohen (ORCID: https://orcid.org/0000-0002-2723-6481)
- AnnaLynn M. Williams (ORCID: https://orcid.org/0000-0002-7042-5851)
- Carrie A. Thompson (ORCID: https://orcid.org/0000-0002-4518-2309)
- Thomas Matthew Habermann (ORCID: https://orcid.org/0000-0003-3532-9132)
- Urshila Durani (ORCID: https://orcid.org/0000-0003-1860-2424)
- Jonathan W. Friedberg (ORCID: https://orcid.org/0000-0002-1420-5563)
- Sairah Ahmed (ORCID: https://orcid.org/0000-0001-7302-8299)
- Nadia Toumeh (ORCID: https://orcid.org/0000-0003-0222-6292)
- Brianna J. Negaard (ORCID: https://orcid.org/0000-0001-7592-8952)
- Allison Rosenthal (ORCID: https://orcid.org/0000-0002-8915-3163)
- Dai Chihara (ORCID: https://orcid.org/0000-0002-1153-2294)
- Eric Mou (ORCID: https://orcid.org/0000-0002-9865-4517)
- Matthew J. Maurer (ORCID: https://orcid.org/0000-0002-1867-0526)
- Carla Casulo (ORCID: https://orcid.org/0000-0003-4998-9932)
- Brad S. Kahl (ORCID: https://orcid.org/0000-0003-0459-6609)
- James R. Cerhan (ORCID: https://orcid.org/0000-0002-7482-178X)
- Christopher R. Flowers (ORCID: https://orcid.org/0000-0002-9524-3990)
- Andrew L. Feldman (ORCID: https://orcid.org/0000-0001-5009-4808)
- Alessandra J. Ainsworth (ORCID: https://orcid.org/0000-0001-7203-5155)
- Melissa C. Larson (ORCID: https://orcid.org/0000-0002-5430-8161)
- Peter W. Martin
- Izidore S. Lossos
Institutions
- University of Iowa (US)
- The University of Texas MD Anderson Cancer Center (US)
- Emory University (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Cancer Institute (WIA) (IN)
- WinnMed (US)
- University of Rochester Medical Center (US)
- Cancer Research Institute of the Slovak Academy of Sciences (SK)
- Mayo Clinic Health System (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
- Sylvester Comprehensive Cancer Center (US)
- European Society for Blood and Marrow Transplantation (FR)
- Weill Cornell Medicine (US)
- University of Rochester (US)
Publication Details
- Journal
- Leukemia & lymphoma/Leukemia and lymphoma
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1080/10428194.2025.2582721
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00