Paradoxical sex differences in a hamster model of angiotensin II-dependent hypertension and associated renal injury
Female Syrian hamsters exhibit heightened vulnerability to Ang II-induced hypertension and renal damage compared to males, marked by exaggerated blood pressure elevation, enhanced renal inflammation, and suppression of classical RAS components. This novel hamster model provides a unique platform for studying sex-specific mechanisms of hypertension and renal pathology, with translational relevance for subpopulations of women who are at increased risk of Ang II-dependent hypertension-associated renal disease.
Authors
- Jungeun Ahn
- L Nascimento (ORCID: https://orcid.org/0009-0000-4167-216X)
- Robert C. Speth (ORCID: https://orcid.org/0000-0002-6434-2136)
- Aline M. A. de Souza (ORCID: https://orcid.org/0000-0002-7031-2523)
- Kathryn Sandberg (ORCID: https://orcid.org/0000-0003-2967-8336)
- Xie Wu (ORCID: https://orcid.org/0000-0001-5027-039X)
- Juan M. Saavedra (ORCID: https://orcid.org/0000-0002-7238-9647)
- Gabrielle Williams (ORCID: https://orcid.org/0000-0001-8670-2326)
- Nisha K. Duggal (ORCID: https://orcid.org/0000-0002-9893-8069)
- Seth A. Hawks (ORCID: https://orcid.org/0000-0001-7742-474X)
- Hong Ji (ORCID: https://orcid.org/0000-0002-1013-565X)
- Dong Hyang Kwon
Institutions
- Georgetown University (US)
- Nova Southeastern University (US)
- Virginia Tech (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s13293-025-00755-y
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nova Southeastern University