Reduced field-of-view diffusion-weighted MRI: a systematic review of technical and clinical insights

Abstract Background Diffusion-weighted imaging (DWI) is a widely used magnetic resonance imaging method for non-invasive assessment of tissue structure. However, conventional Diffusion-weighted imaging (C-DWI) often suffers from low spatial resolution and artifacts. This systematic review evaluates the technical and clinical benefits of Reduced Field-of-View Diffusion-weighted magnetic resonance imaging (rFOV DWI) in comparison to C-DWI techniques. Objective The aim of the present review was to systematically evaluate the technical advances, diagnostic accuracy, and clinical applications of rFOV DWI compared with C-DWI techniques. Study design and methods A systematic review was performed according to PRISMA guidelines. Databases including ScienceDirect, Springer, Elsevier, PubMed/Medline, Wiley Online Library, and Scopus were searched. Eleven eligible studies were identified and reviewed for imaging efficacy, artifact reduction, spatial resolution, and diagnostic utility. Results rFOV DWI significantly improves image clarity by reducing susceptibility and motion artifacts. It enables higher spatial resolution and more accurate visualization of small anatomical structures. Compared to C-DWI, rFOV DWI shows enhanced diagnostic precision, which supports early disease detection and more informed clinical decisions. Conclusion rFOV DWI represents a notable advancement in imaging, offering improved quality and clinical utility. Its enhanced performance supports its integration into routine diagnostic workflows and highlights its potential for broader application as MRI technologies evolve.