Genomic structural equation modeling decodes skeletal aging: novel loci discovery and multisystem genetic crosstalk
This study establishes mvSAge as a genetically cohesive construct and uncovers novel loci, pathways, and multi-system interactions underlying skeletal aging. These findings advance precision medicine strategies for aging-related musculoskeletal disorders.
Authors
- Fangyang Fan
- Tianwei Wang (ORCID: https://orcid.org/0000-0003-4235-6438)
- Bingliang Fang (ORCID: https://orcid.org/0000-0001-9225-3010)
- Xiaohong Mu (ORCID: https://orcid.org/0000-0002-7200-1809)
- Chunxiao Bai
- Ying Zhou (ORCID: https://orcid.org/0000-0002-3727-2128)
- Jinyu Li (ORCID: https://orcid.org/0000-0002-8220-049X)
- Fan Zhang (ORCID: https://orcid.org/0000-0003-0458-6742)
- Liang Xu (ORCID: https://orcid.org/0009-0005-6499-1186)
- Yuquan Wang (ORCID: https://orcid.org/0000-0002-2588-5795)
- Jian Huang (ORCID: https://orcid.org/0000-0002-2253-4586)
Institutions
- Beijing University of Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Xiamen Chang Gung Hospital (CN)
- Xiamen University of Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s12967-025-07104-y
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Beijing University of Chinese Medicine
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund