Surfactant-driven modulation of protein corona on solid lipid nanoparticles: Insights including molecular docking studies

This study demonstrated that protein corona formation on dual-surfactant SLNs is strongly influenced by surface charge and surfactant composition and in turn modulates drug release dynamics. The protein corona was shown to modulate drug release with potential implications for antibacterial efficacy. These findings highlight the importance of tailoring surface properties to control protein-nanoparticle interactions thus providing insight into the design of lipid-based nanoparticles for therapeutic applications.