Elucidating the role of SIRT2 in hepatocellular carcinoma through multi-omics and deep learning
SIRT2 is posited as a pathogenic gene for HCC. It may facilitate the growth and invasion of HCC via multiple mechanisms, including Cuproptosis, tumor microenvironment modulation, metabolic pathway alteration, and immune checkpoint activation. SIRT2 presents as a potential biomarker for HCC and may serve as a novel therapeutic target for its treatment.
Authors
- Caiyuan Yu (ORCID: https://orcid.org/0000-0002-3435-6932)
- Changan Chen (ORCID: https://orcid.org/0009-0002-2926-5419)
- Bo Cai (ORCID: https://orcid.org/0000-0002-4487-6202)
- Shicai Ye (ORCID: https://orcid.org/0009-0005-7663-7379)
- Lijiao Cui (ORCID: https://orcid.org/0009-0000-3059-8451)
- Tingmei Yang
- Zhenkai Li (ORCID: https://orcid.org/0000-0002-8281-9436)
- Yijie Weng (ORCID: https://orcid.org/0009-0009-2893-604X)
Institutions
- Guangdong Medical College (CN)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1007/s12672-025-03879-0
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00