Metformin’s protection against blood-brain barrier disruption and neuronal dysfunction under oxygen-glucose deprivation and tobacco smoke and e-vape chemical exposure
Our findings demonstrate that MF pretreatment could be an effective countermeasure following OGD exposure in conjunction with TSe and ECe exposure, which is often linked to the deterioration of the BBB and possibly mitochondrial function.
Authors
- Sejal Sharma (ORCID: https://orcid.org/0000-0001-5923-2613)
- Thomas J. Abbruscato (ORCID: https://orcid.org/0000-0001-7597-9477)
- Satyawan Jadhav (ORCID: https://orcid.org/0000-0003-0628-2961)
- Yong Zhang (ORCID: https://orcid.org/0000-0001-6577-5235)
- Khondker Ayesha Akter
Institutions
- Texas Tech University (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s12987-025-00719-9
- Citations
- 1
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institutes of Health