Mutational analysis of the mitochondrial tRNA genes and flanking regions in lymphocytes from long-term pediatric cancer survivors given doxorubicin chemotherapy for acute lymphoblastic leukemia
The results of this study indicate that doxorubicin chemotherapy is associated with increases in mtDNA sequence variants in lymphocytes. The role of mtDNA mutations in late-onset cardiomyopathy of doxorubicin, and the potential antimutagenic activity of dexrazoxane, were not established but warrant further investigation.
Authors
- Salina Torres (ORCID: https://orcid.org/0000-0001-7310-7544)
- Yael Flamand (ORCID: https://orcid.org/0000-0003-2150-6732)
- Vernon E. Walker (ORCID: https://orcid.org/0000-0003-0299-7177)
- Dale M. Walker
- Neha M. Bansal (ORCID: https://orcid.org/0000-0001-7026-3058)
- Stephen E. Sallan (ORCID: https://orcid.org/0000-0002-1064-8981)
- Steven E. Lipshultz (ORCID: https://orcid.org/0000-0002-2077-6178)
- Kristen E. Stevenson (ORCID: https://orcid.org/0000-0002-0647-1431)
Institutions
- University of Vermont (US)
- Harvard University (US)
- University of New Mexico (US)
- Mount Sinai Hospital (US)
- Dana-Farber Cancer Institute (US)
- Vermont Space Grant Consortium (US)
- Jacobs Institute (US)
- Jacobs (United States) (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s40959-025-00396-5
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00