IGF1-mediated mesenchymal-endothelial transition as a potential regulatory target in calcific aortic valve disease
We provide the first evidence that VICs have the capability to undergo endothelial transition under calcific conditions and that MEndT occurs in aortic valve of the CAVD mouse model. These findings reveal the presence of MEndT in CAVD, offering a potential therapeutic target.
Authors
- Mi Zhou (ORCID: https://orcid.org/0000-0001-6183-738X)
- Dan Zhu (ORCID: https://orcid.org/0000-0001-6241-4354)
- Binglin Li (ORCID: https://orcid.org/0000-0002-6409-0784)
- Xiaoyan Wang (ORCID: https://orcid.org/0000-0002-5140-676X)
- Tao Lyu (ORCID: https://orcid.org/0000-0002-9107-5619)
- Jianghong Guo
- Tuguang Kuang
Institutions
- Jiangnan University (CN)
- Shanghai Jiao Tong University (CN)
- Nantong University (CN)
- Ruijin Hospital (CN)
- Shanghai Chest Hospital (CN)
- Wuxi Fourth People's Hospital (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s12916-025-04433-z
- Citations
- 1
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39