SPARC-modified mesenchymal stem cells promote recovery of β-cells and insulin secretion by calcium ion homeostasis
SPARC significantly promotes cell regeneration and stimulates insulin secretion by increasing intracellular ATP and Ca<sup>2+</sup> influx. In diabetic canine and mice models, it alleviated hyperglycemia, improved glucose tolerance, and enhanced pancreatic islet area and insulin secretion.
Authors
- Balun Li (ORCID: https://orcid.org/0000-0001-9835-0436)
- Jinlian Hua (ORCID: https://orcid.org/0000-0001-9788-8592)
- Wenfeng Zhu (ORCID: https://orcid.org/0000-0001-8424-3541)
- Zixi Ling
- Jierui Dai
- Changrong Lv
- Na Li (ORCID: https://orcid.org/0000-0002-4112-0944)
- Hongkai Tian
- Zengyu Zhang (ORCID: https://orcid.org/0000-0001-5333-9911)
- Jiaqi Gao
- Chenchen Li
- Dongyao Han
- Lydmila Gerunova
- Nikita Merzlikin
Institutions
- North West Agriculture and Forestry University (CN)
- Northwest A&F University (CN)
- Omsk State Agrarian University (RU)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s13287-025-04727-2
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China