Serum growth differentiation factor 15 trajectory predicts 28-day mortality in critically ill patients: a multicenter cohort study
Serum GDF15 trajectory and GDF15-load are robust predictors of 28-day mortality in ICU patients. GDF15-D1 strongly reflects cumulative GDF15 burden and provides a rapid, practical tool for early risk stratification, especially in postoperative ICU patients. These findings support the use of GDF15 as both a dynamic and point-of-care biomarker in intensive care settings.
Authors
- Yi Han (ORCID: https://orcid.org/0000-0002-2334-5779)
- Xinyi Chang (ORCID: https://orcid.org/0009-0004-8510-469X)
- Qinxue Wang (ORCID: https://orcid.org/0000-0003-0539-5892)
- Nan Zheng (ORCID: https://orcid.org/0000-0002-5365-9680)
- Xiang Li (ORCID: https://orcid.org/0000-0002-5147-8368)
- Jiawei Wang (ORCID: https://orcid.org/0000-0002-8606-6873)
- Yuhan Zhao (ORCID: https://orcid.org/0000-0002-1427-4139)
- Yunfeng Ji (ORCID: https://orcid.org/0000-0002-9676-8211)
- Yuanze Ma
Institutions
- Harbin Medical University (CN)
- Nanjing Maternity and Child Health Care Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-11-03
- DOI
- https://doi.org/10.7717/peerj.20317
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00