Respiratory and Feeding Management of Neonates Admitted with Pierre Robin Sequence in a Tertiary Neonatal Unit: A Case Series

Pierre Robin sequence (PRS) presents unique challenges in neonatal airway and feeding management, with significant variability in strategies across settings and a lack of standardized guidelines. We conducted a 10-year retrospective review of 16 neonates with PRS admitted to a tertiary neonatal unit to evaluate clinical characteristics and management approaches. Three cases were syndromic (PRS-plus), and six neonates required resuscitation at birth. Respiratory support was needed in 75% of cases, ranging from non-invasive methods to tongue–lip adhesion. Feeding difficulties were common, with prolonged support required in six infants and a gastrostomy in one. Half of the cohort exhibited growth faltering during the follow-up. Our experience suggests that individualized, resource-sensitive management of PRS can lead to favorable outcomes, underscoring the need for adaptable care pathways in diverse clinical settings.