Unveiling the expression and mechanistic role of SYCP2 in cervical lesions
SYCP2 emerges as a critical biomarker for HPV-driven cervical carcinogenesis, with diagnostic potential for high-grade lesions and prognostic value for metastasis risk. Its regulatory role in IL13RA2-mediated signaling and association with viral response pathways suggest mechanistic involvement in tumor microenvironment remodeling. The dual context-dependent expression (upregulated in cervical cancer vs. downregulated in other malignancies) highlights tissue-specific oncogenic functions. These findings position SYCP2 as a promising target for HPV-associated cervical cancer screening and therapeutic strategies.
Authors
- Yuanhang Zhu (ORCID: https://orcid.org/0000-0002-0996-7926)
- Xin Yang (ORCID: https://orcid.org/0000-0003-1888-3721)
- Zhenan Zhang (ORCID: https://orcid.org/0000-0002-1684-9450)
- Chenchen Ren
- Chunli Wang (ORCID: https://orcid.org/0000-0001-8891-1797)
- Ling Liu
- Z. L. Hou (ORCID: https://orcid.org/0009-0007-0843-0805)
- Huina Hu
Institutions
- Zhengzhou University (CN)
- Fifth Affiliated Hospital of Zhengzhou University (CN)
- National Engineering Research Center for Wheat (CN)
- Zoucheng People's Hospital (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- Zhengzhou People's Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1007/s12672-025-03894-1
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00