Injectable ultrasonic metagels for intracranial monitoring
Abstract Annually, over 10 million patients undergo high-risk invasive intracranial monitoring, facing risks of infection and secondary surgeries. Injectable ultrasonic metagels, wireless, biodegradable sensors with air-column matrices for multiparameter (pressure, temperature, pH, flow) ultrasound readout, are delivered via 5.8 mm burr-hole/22 G needle (avoiding ≥10 mm craniotomy), enabling ambulatory monitoring. Biodegradation eliminates removal surgery, addressing biocompatibility, fidelity, and deployability. However, unresolved degradation kinetics, motion artifact, and deep-tissue signal require resolution for further clinical translation.
Authors
- Y S Wang (ORCID: https://orcid.org/0009-0004-1647-5761)
- Shumao Xu
- Mingyuan Ge (ORCID: https://orcid.org/0000-0001-5682-7443)
- Ru Wang (ORCID: https://orcid.org/0000-0002-2768-1753)
- Yinghao Zhu (ORCID: https://orcid.org/0000-0003-3744-6615)
Institutions
- Fudan University (CN)
- Shanghai Institute for Science of Science (CN)
- Max Planck Institute for Solid State Research (DE)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
Publication Details
- Journal
- npj Biosensing
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1038/s44328-025-00058-7
- Citations
- 1
- Primary Topic
- Ultrasound Imaging and Elastography
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Natural Science Foundation of China
- Fudan University