The impact of phenotypic- versus target-based approaches in antimalarial drug discovery in the last two decades (2005–2025)

While phenotypic-based drug discovery outperformed the target-based approach, we propose some strategies to improve chances of success in the latter strategy. Furthermore, although antimalarial drug discovery and development has seen an encouraging shift toward more collaborations among industry, academia, and product development partners, R&D in this space remains concentrated in the global north.

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Publication Details

Journal
Future Medicinal Chemistry
Published
2025-11-02
DOI
https://doi.org/10.1080/17568919.2025.2580928
Citations
1
Primary Topic
Malaria Research and Control
Type
article
Field-Weighted Citation Impact
1.88
Controls
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article

The impact of phenotypic- versus target-based approaches in antimalarial drug discovery in the last two decades (2005–2025)

Godfrey Mayoka, Dickson Mambwe, Ayanda I. Zulu, Peter Mubanga Cheuka et al.
1 citations
Future Medicinal Chemistry
Malaria Research and Control
1.88
article

The impact of phenotypic- versus target-based approaches in antimalarial drug discovery in the last two decades (2005–2025)

Godfrey Mayoka, Dickson Mambwe, Ayanda I. Zulu, Peter Mubanga Cheuka, Ameera Mohammed Dawoodjee
article en
1 citations

Abstract

While phenotypic-based drug discovery outperformed the target-based approach, we propose some strategies to improve chances of success in the latter strategy. Furthermore, although antimalarial drug discovery and development has seen an encouraging shift toward more collaborations among industry, academia, and product development partners, R&D in this space remains concentrated in the global north.

Future Medicinal ChemistryVol. 17(23)
Jomo Kenyatta University of Agriculture and Technology (KE), University of Zambia (ZM), Helmholtz Centre for Infection Research (DE), Helmholtz Institute for Pharmaceutical Research Saarland (DE)
Openalex Percentile: Top 11%
Malaria Research and Control
1.88
DOISourceOpenAlex
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The impact of phenotypic- versus target-based approaches in antimalarial drug discovery in the last two decades (2005–2025) — Godfrey Mayoka, Dickson Mambwe, et al. · Future Medicinal Chemistry (2025) | TGRS Research Map | TGRS