Targeting PGC-1α by miRNA-374 Simultaneously Improve β-Cell Dysfunction and Suppress Hepatic Glucose Overproduction
Based on these findings, we propose that Ex-4-CCL-miR-374 as a promising therapeutic approach to reverse β-cell dysfunction and improve hepatic insulin resistance in type 2 diabetes mellitus.
Authors
- Young‐Hye You (ORCID: https://orcid.org/0000-0002-2548-6524)
- Kwan Yong Lee (ORCID: https://orcid.org/0000-0002-0480-1046)
- Kun‐Ho Yoon (ORCID: https://orcid.org/0000-0002-9109-2208)
- Joonyub Lee (ORCID: https://orcid.org/0000-0003-0533-9786)
- Heon‐Seok Park (ORCID: https://orcid.org/0000-0001-7587-6929)
- Cheongeun Oh (ORCID: https://orcid.org/0000-0001-8907-0985)
- Eun Young Lee (ORCID: https://orcid.org/0000-0001-7056-2437)
- Ji-Won Kim (ORCID: https://orcid.org/0000-0002-3806-4873)
- Ji‐Ho Park (ORCID: https://orcid.org/0000-0002-0721-0428)
- Seung-Hyun Ko
Institutions
- Korea Advanced Institute of Science and Technology (KR)
- Korea Institute of Brain Science (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-11-03
- DOI
- https://doi.org/10.4093/dmj.2025.0287
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Korean Diabetes Association
- National Research Foundation
- Seoul National University
- Korea Health Industry Development Institute
- National Research Foundation of Korea