4-Octyl Itaconate Promotes Diabetic Wound Healing by Enhancing Pro-Resolving Macrophages via the Efferocytosis-MCT1-Lactate-GPR132 Pathway and Macrophage-Independent Synergistic Effects
4-OI promotes diabetic wound healing through macrophage-dependent/independent mechanisms. Moreover, the protective effect of 4-OI on macrophage was mediated through MCT1-mediated lactate release triggered by efferocytosis and subsequent GRP132 activation.
Authors
- Yan Zeng (ORCID: https://orcid.org/0000-0002-4083-0127)
- Qiuyue Peng (ORCID: https://orcid.org/0000-0002-4951-9968)
- Yiguo Hu (ORCID: https://orcid.org/0000-0002-3973-2140)
- Yong Xu (ORCID: https://orcid.org/0000-0002-9534-6252)
- Yang Long (ORCID: https://orcid.org/0000-0003-4605-4306)
- Yijun Liu
- Xiaozhen Tan (ORCID: https://orcid.org/0000-0002-7318-7406)
- Charles Q. Jia (ORCID: https://orcid.org/0000-0003-0471-111X)
- Xinxu Ge
- Jiao Chen (ORCID: https://orcid.org/0000-0003-3414-1170)
- Linlin Huang (ORCID: https://orcid.org/0000-0003-0317-4893)
- Man Guo (ORCID: https://orcid.org/0000-0002-3288-1485)
- Mengqin Tu (ORCID: https://orcid.org/0009-0005-4916-1985)
- Xiaoli Zou (ORCID: https://orcid.org/0009-0006-6468-9195)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-11-03
- DOI
- https://doi.org/10.4093/dmj.2024.0579
- Citations
- 1
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.03