Synthesis and characterization of Schiff base derivatives from formic acid hydrazide in the aqueous extracts of Moringa Oleifera leaves

This research discusses the manufacture of new compounds to discover novel effective therapeutics from the formic acid hydrazide compound found in the aqueous extract of Moringa oleifera leaves.It was identified using Gas Chromatography Mass Spectrometry (GC-MS).According to GC-MS analysis, the compounds identified with high percentage peak areas in the aqueous extract include Serinol and formic acid hydrazide (12.85%), which is commonly used as a starting material in the synthesis of antibiotics, pesticides, and pharmaceutical compounds.Unsaturated esters (21.62%) were also detected, along with many other plant-derived substances.These extracts and their derivatives can act as potent antioxidants and anti-inflammatory agents, with potential applications in various fields of medicine and cosmetics.The synthesis of Schiff bases was performed via the condensation of formic acid hydrazide with aromatic amines in the presence of glacial acetic acid.The newly synthesized compounds were tested in vitro as antioxidants and anticancer agents.It was found that these derivatives 3a and 3b achieved high antioxidant activity compared to ascorbic acid.In addition, the activity of the synthesized compounds towards colon cancer has been studied and proven that compound 3a is the higher effective.