Combined effect of chronic inflammation and insulin resistance on stroke: a cohort study and mediation analysis
Chronic inflammation and IR have independent and superimposed effects on new-onset stroke risk and mediate each other. In primary care and public health services, the use of hsCRP and MetS-IR to assess the body's chronic inflammation and IR status and further assess its risk of a new stroke is a simple and effective new approach.
Authors
- Zhiping Duan (ORCID: https://orcid.org/0009-0007-1893-7239)
- Yan Zhao (ORCID: https://orcid.org/0000-0001-9475-1275)
- Sicheng Du
- Jingkuo Li (ORCID: https://orcid.org/0000-0002-7806-5387)
- Lijun Song (ORCID: https://orcid.org/0000-0003-2051-8643)
- Yan Hou (ORCID: https://orcid.org/0009-0003-6504-9745)
- Ran Zhao (ORCID: https://orcid.org/0000-0002-5887-5980)
- Ying Li (ORCID: https://orcid.org/0009-0005-8079-1635)
- Yu Gao (ORCID: https://orcid.org/0009-0004-0271-7571)
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Third People's Hospital of Yunnan Province (CN)
- Dali University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s40001-025-03375-9
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yunnan Provincial Department of Education