ATP release and metabolism by human and guinea pig airways and P2X receptor‐dependent effects on bronchopulmonary vagal afferent nerve subtypes
These results predict a desirable safety profile for P2X receptor blockade and identify multiple potential biomarkers that may differentiate responders from non-responders in studies evaluating P2X blockers in chronic cough patients.
Authors
- Bradley J. Undem (ORCID: https://orcid.org/0000-0001-5299-9029)
- Makoto Inoue (ORCID: https://orcid.org/0000-0003-0804-7439)
- Brendan J. Canning (ORCID: https://orcid.org/0000-0003-4197-5560)
- Takanori Tsujimura (ORCID: https://orcid.org/0000-0003-4552-8813)
- Midori Yoshihara (ORCID: https://orcid.org/0000-0003-2022-1874)
- Qi Liu (ORCID: https://orcid.org/0000-0003-2106-7231)
- Nanako Mori
- Sonya Meeker
Institutions
- Johns Hopkins University (US)
- Niigata University (JP)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1111/bph.70238
- Citations
- 3
- Primary Topic
- Respiratory and Cough-Related Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56