Adolescent mice exhibit lower reward sensitivity than adults
These findings challenge the prevailing assumption that adolescent reward sensitivity universally enhances reward-context learning. Instead, we propose that the attenuated CPP observed in adolescence reflects lower reward sensitivity in emotionally neutral conditions, rather than deficits in associative learning or increased novelty seeking. Our results highlight how developmental stage influences reward-related behaviors and underscore the need for age- and sex-specific analyses in behavioral studies.
Authors
- Łukasz Szumiec (ORCID: https://orcid.org/0000-0001-8962-1273)
- Marta Klimczak (ORCID: https://orcid.org/0000-0003-0653-4030)
- Klaudia Misiołek (ORCID: https://orcid.org/0000-0003-1379-2118)
- Maria Kaczmarczyk-Jarosz (ORCID: https://orcid.org/0000-0003-1581-2506)
- Jan Rodriguez Parkitna
- Barbara Ziółkowska (ORCID: https://orcid.org/0000-0002-6782-7737)
- Zofia Harda (ORCID: https://orcid.org/0000-0001-7183-2195)
- Magdalena Chrószcz (ORCID: https://orcid.org/0000-0002-3157-458X)
- Aleksandra Rzeszut
- Julia Netczuk (ORCID: https://orcid.org/0000-0003-1986-2877)
Institutions
- Maj Institute of Pharmacology (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Frontiers in Behavioral Neuroscience
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fnbeh.2025.1695375
- Citations
- 1
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.91