Focal postnatal deletion of Tsc2 causes epilepsy
A focal, postnatal deletion of <i>Tsc2</i> from cortical neurons is sufficient to cause both epilepsy and behavioral deficits in mice. This model recapitulates key phenotypes of TSC, including abnormal cell growth, reduced inhibitory cell density, and increased microglia activation. This fTSC2 KO model is advantageous for delineating the cortical changes that support epilepsy and behavioral deficits in TSC, and for investigating possible targets for therapeutic intervention.
Authors
- Jacques Otten (ORCID: https://orcid.org/0000-0002-0491-8623)
- Lilian G Jerow
- Steve C. Danzer (ORCID: https://orcid.org/0000-0003-4405-2999)
- Carlie McCoy (ORCID: https://orcid.org/0000-0001-5930-8438)
- Mary R. Dusing
- Candi L. LaSarge (ORCID: https://orcid.org/0000-0001-6903-8080)
- Jason L. Rogers
- Grace C. Winstel
- Felix Zhan
- Madison Wesley
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Noldus Information Technology (NL)
- University of Cincinnati (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fnmol.2025.1686023
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00