IgG subclass-specific N-glycosylation differentiates HRCT subtypes in idiopathic inflammatory myopathies-associated ILD
Subclass-specific IgG N-glycosylation profiles reflect the immunological heterogeneity underlying IIM-ILD. Integrating these glycan signatures with routine clinical data creates a strong model for distinguishing HRCT-defined endotypes, supporting their potential to improve disease classification and guide future mechanistic research in autoimmune-related ILD.
Authors
- Yingying Ling (ORCID: https://orcid.org/0009-0006-2768-2410)
- Yubin Luo (ORCID: https://orcid.org/0000-0002-7669-1579)
- Yinlan Wu (ORCID: https://orcid.org/0000-0002-0188-8676)
- Chunyu Tan (ORCID: https://orcid.org/0009-0004-1068-5995)
- Yi Liu (ORCID: https://orcid.org/0000-0003-4462-3210)
- Yong Zhang (ORCID: https://orcid.org/0000-0003-0513-8941)
- Cheng Lu (ORCID: https://orcid.org/0000-0002-8577-4288)
- Tong Wu (ORCID: https://orcid.org/0009-0001-1733-2517)
- Jing Zhao (ORCID: https://orcid.org/0000-0003-4919-0530)
- Yanhong Li
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1696126
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China