Effects of cavity depth (moderate vs. deep with pulp exposure) on the release of prostaglandin E2 and nitric oxide in rat mandibular incisors

Cavity preparation induces an early inflammatory response in the pulp, as indicated by increased PGE2 and NO levels. The inflammatory response was more pronounced in cavities without pulp exposure, suggesting that maintaining pulp integrity favors a regulated inflammatory response conducive to healing, while exposure may promote irreversible damage.