Is there an alternative to the indirect immunofluorescence ANA HEp-2 assay for the diagnosis of connective tissue diseases?
These findings suggest that SPA can serve as a complementary approach to IIF for ANA screening in the diagnosis of AARD. The MAGLUMI assay could be used for initial screening alongside IIF, depending on the clinical context. A proper adjustment of the threshold of the MAGLUMI ANA Screen assay may improve its specificity and limit false positive results.
Authors
- Meriem Saad
- Réda Djidjik (ORCID: https://orcid.org/0000-0003-0820-692X)
- Lydia Lamara Mahammed (ORCID: https://orcid.org/0000-0002-5360-8066)
- H Ismail (ORCID: https://orcid.org/0009-0006-0433-5176)
- Ines Allam
- Tamazouzt Hadjout
- Ghalya Bousbia
- Nawel Dahmani
- Nadia Tamechmacht
- Amel Zemmour
Institutions
- University of Algiers Benyoucef Benkhedda (DZ)
- University of Algiers 3 (DZ)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1669124
- Citations
- 1
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.52