Functional and clinical validation of tsRNA-defined molecular subtypes guides precision therapy in gastric cancer
Our study establishes tsRNAs as powerful biomarkers for molecular subtyping and prognostic prediction in GC. The tsRNA-defined subtypes and GCtsRNAscore model provide a novel framework for personalized treatment strategies. The functional characterization of tsRNA-Asp-3-0024 highlights its potential as both a therapeutic target and a prognostic indicator, paving the way for tsRNA-based precision medicine in GC.
Authors
- Huahuan Liu
- Yubei Huang (ORCID: https://orcid.org/0000-0002-6299-7112)
- Yuan Pan (ORCID: https://orcid.org/0000-0001-7115-5040)
- Hong Dai (ORCID: https://orcid.org/0000-0002-3009-5536)
- Wenqi Wu (ORCID: https://orcid.org/0000-0002-3923-3093)
- Yan Cui (ORCID: https://orcid.org/0000-0002-4913-1285)
- Changyu Sun (ORCID: https://orcid.org/0000-0002-3964-1783)
- Fengju Song
- Yanxin Yao (ORCID: https://orcid.org/0000-0002-1485-9831)
- Liqing Jia (ORCID: https://orcid.org/0000-0003-1734-6043)
- Ye Tian (ORCID: https://orcid.org/0000-0002-5662-2920)
- Yuan Liu (ORCID: https://orcid.org/0000-0001-6227-024X)
- Wei Wang (ORCID: https://orcid.org/0000-0002-8180-2886)
- Ben Liu (ORCID: https://orcid.org/0000-0001-8452-5397)
- Kexin Chen (ORCID: https://orcid.org/0000-0003-1010-8093)
- Fubing Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Xiangnan Zhang (ORCID: https://orcid.org/0000-0001-6768-1697)
- Xin Hu (ORCID: https://orcid.org/0000-0002-0124-6032)
- Zun Li (ORCID: https://orcid.org/0000-0003-1748-0883)
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Wuhan University (CN)
- Wuhan Institute of Virology (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1684113
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00