Diagnostic study of serum claudin-3 and zonulin for intestinal barrier dysfunction after abdominal surgery
Following intestinal mucosal injury, the greater the degree of damage, the higher the concentrations of serum claudin-3 and zonulin, which are positively correlated, peaking at 24 h post-operation. Serum claudin-3 and zonulin have good predictive value for postoperative intestinal barrier dysfunction, with serum claudin-3 demonstrating a higher diagnostic value than serum zonulin for postoperative intestinal barrier dysfunction.
Authors
- Fuyang Jiang (ORCID: https://orcid.org/0000-0001-5055-8932)
- Yichen Hu (ORCID: https://orcid.org/0000-0002-0720-583X)
- YuanPei Zhao
- W J Liu (ORCID: https://orcid.org/0000-0001-7400-7385)
- Weiming Li (ORCID: https://orcid.org/0000-0001-9220-514X)
- Jie Huang
- Xiaolan Gong (ORCID: https://orcid.org/0009-0009-1530-449X)
Institutions
- Hebei Medical University (CN)
- Kunming Medical University (CN)
- Xingtai People's Hospital (CN)
- Zhujiang Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fmed.2025.1669630
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Kunming Medical University