Echinococcus granulosus antigen B ameliorates myocardial infarction through promoting M2 macrophage polarization
These findings reveal that r<i>Eg</i>AgB8/2 ameliorates MI in mice by promoting macrophage polarization from M1 to M2 phenotypes through inhibition of the NLRP3/caspase-1/IL-1β signaling pathway, indicating its potential as a therapeutic agent for MI and other inflammation-related diseases.
Authors
- Shili Wu (ORCID: https://orcid.org/0009-0001-9266-0799)
- Bin Zhan (ORCID: https://orcid.org/0000-0002-6884-9452)
- Erhe Gao (ORCID: https://orcid.org/0000-0002-5151-7857)
- Bingxin Liu (ORCID: https://orcid.org/0000-0001-9835-9983)
- Xinlong Xu (ORCID: https://orcid.org/0000-0002-3034-810X)
- Weixiao Zhang (ORCID: https://orcid.org/0000-0002-8096-1826)
- Rui Zhou (ORCID: https://orcid.org/0000-0002-0782-4761)
- Sai Wang (ORCID: https://orcid.org/0000-0002-6885-6505)
- Rui Wang (ORCID: https://orcid.org/0009-0003-1516-3865)
- Hui Wang (ORCID: https://orcid.org/0000-0002-2346-8621)
- Chen Yang (ORCID: https://orcid.org/0000-0001-9876-724X)
- Qiwang Jin
- Xiaodi Yang (ORCID: https://orcid.org/0000-0002-7411-5797)
Institutions
- Bengbu Medical College (CN)
- Baylor College of Medicine (US)
- Jiangsu Cancer Hospital (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Temple University (US)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fcimb.2025.1662758
- Citations
- 1
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Natural Science Foundation of Anhui Province