Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments
In summary, extraction timepoint and seeding cell number are the two critical parameters to consider before initiating a CYP expression experiment with HepaRG cells.
Authors
- Philip Marx‐Stoelting (ORCID: https://orcid.org/0000-0002-6487-2153)
- Veronika Städele (ORCID: https://orcid.org/0000-0002-5381-2198)
- Kristina Jochum
Institutions
- Federal Institute for Risk Assessment (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fphar.2025.1690384
- Primary Topic
- Gene expression and cancer classification
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesinstitut für Risikobewertung