Impact of the Warburg effect on nucleotide homeostasis in human retinal endothelial cells and its relevance to proliferative diabetic retinopathy
Exposure to HG and Hyp, key risk factors for PDR, disrupts nucleotide homeostasis in HRECs, with enhanced glycolytic flux fueling nucleotide precursor production and altered kinase expression favoring the accumulation of nucleoside mono- and diphosphates over triphosphates. The corresponding increase in AMP and ADP in PDR vitreous highlights their potential as biomarkers and underscores the central role of nucleotide metabolism in PDR pathogenesis.
Authors
- J.C.Dean Hart
- Shaimaa Eltanani
- Xihui Lin (ORCID: https://orcid.org/0000-0002-6067-9954)
- Ahmed M. Awad (ORCID: https://orcid.org/0000-0002-6211-4105)
- Thangal Yumnamcha
- Ahmed S. Ibrahim (ORCID: https://orcid.org/0000-0001-8480-6252)
- Andrew Gregory (ORCID: https://orcid.org/0009-0004-1018-519X)
- Mohamed Shawky
- Rao Me
Institutions
- Damietta University (EG)
- Mansoura University (EG)
- Wayne State University (US)
- The Barbara Ann Karmanos Cancer Institute (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fphar.2025.1660067
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00