The analysis reveals novel hub genes and pathways associated with Tetralogy of Fallot
This study identified that TOF DEGs are highly enriched in fatty-acid beta-oxidation and related pathways. The snRNA-seq data of TOF showed that fatty acid metabolism pathways are predominantly enriched in cardiomyocytes. These findings contribute to further understanding the potential pathogenic mechanisms of TOF and identifying potential therapeutic targets.
Authors
- Lei Peng (ORCID: https://orcid.org/0000-0002-1206-2327)
- Heling Wen (ORCID: https://orcid.org/0000-0002-7629-1882)
- Wenjie Tian (ORCID: https://orcid.org/0000-0002-9896-1154)
- Zheng Huang (ORCID: https://orcid.org/0000-0003-0033-8565)
- Yujie Mao (ORCID: https://orcid.org/0000-0003-1096-9408)
- Yu Chen (ORCID: https://orcid.org/0000-0001-9926-2518)
Institutions
- University of Electronic Science and Technology of China (CN)
- Chengdu Medical College (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fcvm.2025.1604939
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00