Integrative pharmacovigilance and AI-based framework uncovers potential drug triggers in juvenile idiopathic arthritis
In this study, we identify lansoprazole as a likely instigator of systemic juvenile idiopathic arthritis, underscoring that proton-pump inhibitors should be used judiciously in children at autoimmune risk and providing a generalizable playbook for rare-disease pharmacovigilance.
Authors
- Hongmei Song (ORCID: https://orcid.org/0000-0001-9801-2517)
- Haiguo Yu (ORCID: https://orcid.org/0000-0001-8255-9390)
- Xinlin Wu
- Yuxiao Chen (ORCID: https://orcid.org/0000-0001-7597-246X)
- H. J. Yang (ORCID: https://orcid.org/0009-0004-8274-9863)
- Junfeng Wu
- Dawei Liu (ORCID: https://orcid.org/0000-0002-6995-3606)
- Qiang Luo (ORCID: https://orcid.org/0000-0001-6813-4820)
- Jingyi Zhao (ORCID: https://orcid.org/0000-0002-3125-2716)
- Xuemei Tang (ORCID: https://orcid.org/0000-0002-4476-506X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Nanjing Children's Hospital (CN)
- Chengde Medical University (CN)
- Shenzhen Children's Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1653003
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chengde Medical University
- Chongqing Municipal Education Commission
- Centre Scientifique et Technique du Bâtiment
- National Key Research and Development Program of China