Expression and prognostic value of FKBP51 in Hodgkin lymphoma
FKBP51 expression in CD4 tumor-infiltrating lymphocytes, rather than tumor cells, defines a protumor TME that supports H/RS cell survival. Spatial immune architecture, particularly CD4 rosettes and TAM density, holds prognostic relevance in HL. FKBP51 may serve as a biomarker for risk stratification.
Authors
- Massimo Mascolo (ORCID: https://orcid.org/0000-0002-2576-220X)
- Elena Vigliar (ORCID: https://orcid.org/0000-0003-2856-9023)
- Gennaro Acanfora (ORCID: https://orcid.org/0000-0002-0803-0293)
- Silvia Varricchio (ORCID: https://orcid.org/0000-0003-4984-0046)
- Fabrizio Pane (ORCID: https://orcid.org/0000-0003-2563-4125)
- R Cappiello
- Marco Picardi (ORCID: https://orcid.org/0000-0001-8508-2524)
- Marcello Persico
- Antonio Travaglino (ORCID: https://orcid.org/0000-0003-4002-1618)
- Laura Marrone (ORCID: https://orcid.org/0000-0002-1595-0928)
- Daniela Russo (ORCID: https://orcid.org/0000-0002-6961-3695)
- Simona Romano (ORCID: https://orcid.org/0000-0002-9401-5814)
- Gennaro Ilardi (ORCID: https://orcid.org/0000-0002-9354-4087)
- Mariarosaria Cervasio
- Maria Fiammetta Romano
Institutions
- University of Insubria (IT)
- Federico II University Hospital (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1604920
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00