A study on neurotransmitter levels in rats with Tic disorder treated with aripiprazole
ARI can regulate motor and stereotypic behaviors in TD rats and effectively control tic symptoms. TD rats exhibit dysregulation of Glu and GABA levels, and ARI can modulate Glu and GABA levels, thereby improving neurotransmitter function. Furthermore, central neurotransmitter changes demonstrate superior diagnostic value over peripheral measures for TD.
Authors
- Zhisheng Liu (ORCID: https://orcid.org/0000-0002-1454-9454)
- Yingying Xin
- Xue Yang (ORCID: https://orcid.org/0000-0001-7724-7632)
- Huimin Chen (ORCID: https://orcid.org/0000-0002-5241-2408)
- Yang Wang (ORCID: https://orcid.org/0000-0002-8637-207X)
- Dan Sun (ORCID: https://orcid.org/0000-0003-4513-7046)
Institutions
- Wuhan Children's Hospital (CN)
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fnins.2025.1691717
- Citations
- 1
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.31
Funders
- Huazhong University of Science and Technology
- Tongji University
- Tongji Medical College, Huazhong University of Science and Technology