Challenges and strategies for nose-to-brain delivery in treating neurological disorders
Despite the remarkable preclinical progress in enhancing brain drug concentrations, the clinical translation of nose-to-brain nanoplatforms remains hindered by challenges related to long-term safety, inter-individual variability, and scalable manufacturing; future success hinges on the development of intelligent, responsive systems and interdisciplinary collaboration to achieve personalized and effective neurological therapies.
Authors
- Fan Tong (ORCID: https://orcid.org/0000-0002-4333-0128)
- Xi Li (ORCID: https://orcid.org/0000-0002-9753-6148)
- Huile Gao (ORCID: https://orcid.org/0000-0002-5355-7238)
- Tao Liu (ORCID: https://orcid.org/0000-0002-0997-7294)
- Xiaorong Wang (ORCID: https://orcid.org/0000-0002-2099-9769)
- Hanmei Li (ORCID: https://orcid.org/0000-0003-3648-6041)
Institutions
- Sichuan University (CN)
- Chengdu University (CN)
- Hainan General Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Expert Opinion on Drug Delivery
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1080/17425247.2025.2583254
- Citations
- 1
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.79