Mechanism of active component β-sitosterol from Myristica fragrans inducing apoptosis in bladder cancer cells via regulating the BCL-2/BAX/caspase-3 pathway
This study demonstrates that β-sitosterol, a major bioactive compound of nutmeg, suppresses bladder cancer progression by modulating the BCL-2/Bax/Caspase-3 axis and PI3K-Akt signaling pathway. These findings provide novel insights into the therapeutic potential of nutmeg as a complementary strategy for bladder cancer treatment.
Authors
- Zhao Tang
- Haozhe Jiang
- Yongkang Zhu
- Hao Pan (ORCID: https://orcid.org/0009-0004-3771-336X)
- Zhen Zhang (ORCID: https://orcid.org/0000-0003-0899-1139)
- Huiqing Zhang (ORCID: https://orcid.org/0000-0001-8915-0563)
- Dongyang Gao
- Z P Lu
Institutions
- Henan Institute of Technology (CN)
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Xinxiang University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fonc.2025.1698721
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 0.00