Combined Omega-3 Fatty Acid and Folic Acid Supplementation Reduces Neonatal Hypoxic-Ischemic Brain Injury via Anti-inflammatory and Anti-apoptotic Mechanisms
The PUFA and FA reduced HI-induced brain infarct size, with the combination showing greater protection compared to individual effects. Both improved cognitive performances, decreasing latency times and enhancing swimming velocity. The PUFA-FA supplementation synergistically restored memory, learning, and motor functions, highlighting strong neuroprotective effects against HI-induced neuronal degeneration and cognitive impairments.
Authors
- S. Mishra (ORCID: https://orcid.org/0000-0003-0907-9256)
- Vinod Kumar Verma (ORCID: https://orcid.org/0000-0002-5740-0123)
- Wendong Sun
- Tanu Ojha
Institutions
- University of Lucknow (IN)
- Chhatrapati Shahu Ji Maharaj University (IN)
- Baoding People's Hospital (CN)
Publication Details
- Journal
- Iranian journal of pharmaceutical research
- Published
- 2025-10-24
- DOI
- https://doi.org/10.5812/ijpr-163943
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00