Comprehensive transcriptomic profiling reveals tissue-specific molecular signatures and dysregulated pathways in human diabetic foot ulcers
DFUs are driven by a dual pathology of inflammatory amplification and metabolic shutdown, overlaid with distinct tissue-specific alterations. Key targets such as chemokine signaling, PPAR-mediated metabolism, and senescence factors emerge as promising candidates for precision therapies aimed at restoring inflammatory-metabolic balance and enhancing wound healing.
Authors
- Sawar Khan
- Gensheng Hu (ORCID: https://orcid.org/0000-0002-0181-0748)
- Yonghan He (ORCID: https://orcid.org/0000-0003-4409-4590)
- Wen Li (ORCID: https://orcid.org/0000-0002-6807-479X)
- Guiqin Zhang (ORCID: https://orcid.org/0009-0005-6879-8025)
- Ayesha Nisar
- Hui Sun
- Haoling Cui
- Enfang Zhu
Institutions
- Central South University (CN)
- University of Lahore (PK)
- Harbin Medical University (CN)
- Kunming Institute of Zoology (CN)
- Second People's Hospital of Yunnan Province (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Third People's Hospital of Yunnan Province (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fendo.2025.1669205
- Citations
- 1
- Primary Topic
- Diabetic Foot Ulcer Assessment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences