Non-neuronal cholinergic stimulation favors bone mass accrual
Taken together, our findings indicate that peripheral cholinergic stimulation promotes bone mass accrual, in part through IL-17-mediated osteoblast activity. Although the evidence is correlative, these results highlight a potential neuro-immune pathway and suggest new therapeutic directions for enhancing bone formation and regeneration.
Authors
- Hazem Eimar
- Garthiga Manickam
- Ahmed Ebraheem Al Subaie
- Iskandar Tamimi (ORCID: https://orcid.org/0000-0003-4196-5151)
- Faleh Tamimi (ORCID: https://orcid.org/0000-0002-4618-8374)
- Lina Abu Nada (ORCID: https://orcid.org/0000-0001-9815-6393)
- Sharifa Alebrahim (ORCID: https://orcid.org/0000-0001-9232-0850)
- Monzur Murshed (ORCID: https://orcid.org/0000-0003-0156-0758)
Institutions
- University of Jordan (JO)
- McGill University Health Centre (CA)
- Shriners Hospitals for Children - Canada (CA)
- University of Sharjah (AE)
- McGill University (CA)
- Qatar University (QA)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.3389/fphys.2025.1684102
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Réseau de Recherche en Santé Buccodentaire et Osseuse
- Fondation de l’Ordre des dentistes du Québec
- Ministry of Education, India
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé